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The modular architectures of Cullin-RING E3 Ligases (CRLs). (A) CRL1 ubiquitin ligase complexes are perhaps the best known examples and bind their substrates via an F-box containing subunit. D'Angiolella and his laboratory discovered functions of cyclin ...
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Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases* - Journal of Biological Chemistry
The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation | PLOS Computational Biology
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Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination* - Journal of Biological Chemistry
Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire | PLOS Computational Biology
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